Search results for " PMA"
showing 6 items of 6 documents
EVALUATION OF OOCYTE QUALITY IN GRANULOSA AND CUMULUS CELLS OF PATIENTS UNDERGOING PMA
2019
Background. We investigate the apoptosis rate of individual granulosa cell–oocyte and cumulus cell–oocyte (COC), associated with the levels of molecules playing a critical role in the regulation of cell death or survival. These molecular analyses have been done to verify the difference of competence between oocytes producing embryos able to reach the blastocyst stage compared with embryos arrested during the in vitro culture. Methods. From each single follicle: granulosa cells were processed for Western blotting analyses, using the following antibodies: pAKT, ERK 1/2, pERK 1/2; cumulus cells were used for in situ immunofluorescence with the same antibodies. DNA fragmentation rate was measur…
Macrophage MerTK promotes profibrogenic cross-talk with hepatic stellate cells via soluble mediators
2022
Background & aims: Activation of Kupffer cells and recruitment of monocytes are key events in fibrogenesis. These cells release soluble mediators which induce the activation of hepatic stellate cells (HSCs), the main fibrogenic cell type within the liver. Mer tyrosine kinase (MerTK) signaling regulates multiple processes in macrophages and has been implicated in the pathogenesis of non-alcoholic steatohepatitis-related fibrosis. In this study, we explored if MerTK activation in macrophages influences the profibrogenic phenotype of HSCs. Methods: Macrophages were derived from THP-1 cells or differentiated from peripheral blood monocytes towards MerTK+/CD206+/CD163+/CD209- macrophages. Th…
Promuovere l’inclusione attraverso il Programma Motorio Abilità Diverse
2023
Gli studi svolti nell’ambito delle neuroscienze, delle scienze motorie e le conseguenti applicazioni didattiche, hanno posto in evidenza la necessità di avviare processi di progettazione e organizzazione dei contenuti, delle modalità organizzative e delle metodologie in educazione fisica e nell’avviamento allo sport, per integrare e modulare fattori inerenti la quantità inclusiva e promuovere pratiche adattive e preventive per raggiungere sempre più persone con diverse esigenze. Le politiche nazionali e sovranazionali, attraverso il PNRR, sottolineano come l’educazione motoria rivesta un ruolo privilegiato per contrastare i fenomeni dell’esclusione e della marginalizzazione, nel periodo com…
L'IMPATTO DELLA DIAGNOSI DI STERILITÀ E DEI TRATTAMENTI DI PMA SULL'UOMO: UNA RASSEGNA DELLA LETTERATURA
2016
Questo contributo prende in esame i vissuti e l’adattamento dell’uomo a seguito della diagnosi di sterilità, nonché il suo approccio ai percorsi di PMA e le principali differenze con l’esperienza femminile. In realtà, il principale focus di interesse della maggior parte degli studi risulta essere la componente femminile della coppia mentre è ormai noto come la genitorialità risulti essenziale anche per l’identità maschile e la mancata transizione ad essa possa determinare nell’uomo gravi ricadute in termini di bassa autostima, alterazione dell’immagine corporea, percezione della propria mascolinità. Il lavoro è orientato ad identificare quali componenti psicologiche giocano un ruolo nell’e…
In human cumulus cells, the apoptotic rate may be considered an indicator for the selection of embryos to improve ongoing pregnancy and implantation …
2014
In order to identify the embryos with higher implantation potential to increase the clinical outcomes after ICSI, the apoptotic rate in human cumulus cells for the embryo selection on day 3, as an adjunct to morphology evaluation, could be considered a new tool compared with embryo selection by morphology alone. Several studies have demonstrated a lower cumulus cell apoptotic rate in women who achieved pregnancy compared with women who did not become pregnant after ICSI. A prospective randomized observational study on 76 ICSI patients was performed before Ovum Pick-Up. Patients were randomized into either the control group (embryo selection by morphology only, A group: 48 patients) or the t…
Juridisko profesiju kvalifikācijas atzīšana darba ņēmēju pārvietošanās, uzņēmējdarbības un pakalpojumu sniegšanas brīvību ietvaros
2020
. Eiropas Savienības pilsoņiem, ir tiesības brīvi veikt uzņēmējdarbību un sniegt pakalpojumus, citās dalībvalstīs. Šo tiesību īstenošana ir atkarīga no darbībām, kuras persona vēlas veikt, jo pastāv profesijas, kuru praktizēšanai ir nepieciešamas īpašas zināšanas un iemaņas, un tām var tikt noteiktas papildus prasības. Pie tādām profesijām pieder arī advokāti un notāri. Dalībvalstu izvirzītie nosacījumi šīm profesijām var traucēt un apgrūtināt, ar Līgumu par Eiropas Savienības darbību, noteiktās pamatbrīvības. Tādēļ ir svarīgi, lai šīs prasības tiktu noteiktas bez diskriminācijas un tās būtu pamatotas ar objektīviem apsvērumiem. Tā kā dalībvalstu izvirzītās prasības noteiktās profesijās var…